The Plaschka lab has an open position for a Master’s student at the Research Institute of Molecular Pathology (IMP) to study a key step in human mRNA processing.
The successful candidate will carry out research on an essential multi-subunit complex involved in mRNA processing. He/she will be exposed to a variety of molecular biology techniques, including biochemical preparation of the complex from insect cells (cloning, purification), structure determination by cryo-electron microscopy (cryo-EM), and functional assays.
The ideal applicant will be highly motivated, have a strong interest in structural biology and have experience in standard biochemistry methods. We offer an exciting research project, outstanding infrastructure, and an excellent opportunity to learn both biochemistry and cryo-EM. The position is available from winter 2024 and remains open until filled. The student will receive a monthly stipend.
To apply please send a CV and cover letter to:
Dr. Clemens Plaschka
clemens.plaschka[at]imp.ac.at;
www.imp.ac.at; www.viennabiocenter.org
Further reading
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Vorländer, M. K., Rothe, P., Kleifeld, J., Cormack, E., Veleti, L., Riabov-Bassat, D., Fin, L., Phillips, A. W., Cochella, L., Plaschka, C. (2024): Mechanism for the initiation of spliceosome disassembly. Nature.
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Pacheco-Fiallos, B., Vorländer, MK., Riabov-Bassat, D., Fin, L., O'Reilly, FJ., Ayala, FI., Schellhaas, U., Rappsilber, J., Plaschka, C. (2023) mRNA recognition and packaging by the human transcription-export complex. Nature.
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T. Pühringer*, U. Hohmann*, L. Fin, B. Pacheco-Fiallos, U. Schellhaas, J. Brennecke, C. Plaschka. Structure of the human core transcription-export complex reveals a hub for multivalent interactions. eLife (2020) 9, e61503. *Equal contribution.
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C. Plaschka*#, P.-C. Lin*#, C. Charenton, K. Nagai#. Prespliceosome structure provides insight into spliceosome assembly and regulation. Nature (2018) 558, 419-422. *Equal contribution. #Co-corresponding authors.
- C. Plaschka*#, P.-C. Lin*#, K. Nagai#. Structure of a pre-catalytic spliceosome. Nature (2017) 546, 617-621. *Equal contribution. #Co-corresponding authors.