Publications

Predictive design of tissue-specific mammalian enhancers that function in the mouse embryo.

Generation of high-quality reference control panels of human induced pluripotent stem cell clones from fibroblasts.

Generation of high-quality reference control panels of human induced pluripotent stem cell clones from PBMCs.

Urinary multi-omics reveal non-invasive diagnostic biomarkers in clear cell renal cell carcinoma.

Cellular assembly and functional resilience of the mammalian RNA exosome.

BRIDGE: an interactive application for multi-omics data analysis, visualization and integration.

ER-mitochondria contacts and mitochondrial fusion correlate with increased mitochondrial activity during vertebrate embryogenesis.

Molecular basis of polyadenylated RNA fate determination in the nucleus.

Tumor sialylation regulates G-CSF stability and promotes neutrophil-mediated immunosuppression in breast cancer.

PAM1 regulates meiosis by coupling RNA processing to the chromosome axis.

Stress and conflict management in core facilities-News from an imaging survey.

Structure of cytoplasmic RNA polymerase II.

The SPARK complex forms the molecular basis of vertebrate fertilization

Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22.

PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes.

The microprotein SMIM26 connects metabolite transporters of the outer and inner mitochondrial membranes and is essential for respiratory chain function.

Low-resolution FAIMS for increased peptide coverage in low-load and single-cell proteomics.

A mammalian-like piRNA pathway in Axolotl reveals the origins of piRNA-directed DNA methylation.

BacPROTAC-induced protein degradation as a new antibiotic concept.

Functional genomic screens uncover FERMT2 as a critical regulator of YAP/TAZ-driven tumorigenicity.

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities.

Poxvirus attack of antiviral defense pathways unleashes an effector-triggered NF-κB response.

A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

Reciprocal zebrafish-medaka hybrids reveal maternal control of zygotic genome activation timing

A multivalent adaptor mechanism drives the nuclear import of proteasomes.

PARG regulates the proteasomal degradation of TARG1.

In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation.

The cotranslational cycle of the ribosome-bound Hsp70 homolog Ssb.

A comprehensive view on r-protein binding and rRNA domain structuring during early eukaryotic ribosome formation.

BORC assemblies integrate BLOC-1 subunits to diversify endosomal trafficking functions.

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.

Structural basis for substrate recruitment and catalytic ubiquitin transfer by the E2/E3 hybrid enzyme UBE2O.

Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo.

Loss-of-function genetic screen unveils synergistic efficacy of PARG inhibition with combined 5-fluorouracil and irinotecan treatment in colorectal cancer.

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways.

MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia.

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma.

Two CTCF motifs impede cohesin-mediated DNA loop extrusion.

Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants.

Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice.

Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape.

Breaking barriers in crosslinking mass spectrometry with enhanced throughput and sensitivity using Orbitrap Astral.

An ATP-gated molecular switch orchestrates human mRNA export

Acidosis orchestrates adaptations of energy metabolism in tumors.

Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-κB, JAK/STAT5 and JNK signalling.

Collective homeostasis of condensation-prone proteins via their mRNAs.

Mechanisms of Messenger RNA Packaging and Export.

ArchVelo: Archetypal Velocity Modeling for Single-cell Multi-omic Trajectories.

Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22.

Trio fatale: Neutrophils, NETs, and necrosis.

Target RNA recognition drives PIWI∗ complex assembly for transposon silencing.

PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes

Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control.

A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles.

Quantitative profiling of human brain organoid cell diversity across four protocols and multiple cell lines.

The mitotic STAG3-cohesin complex shapes male germline nucleome.

CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression.

Coping with uncertainty: Challenges for robust pattern formation in dynamical tissues.

In vivo crosslinking and effective 2D enrichment for proteome wide interactome studies.

DIY innate immune sensing: Crafting fresh DNA to detect viruses.

NIPBL and STAG1 enable loop extrusion by providing differential DNA-cohesin affinity.

SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity.

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ.

A lyophilized open-source RT-LAMP assay for molecular diagnostics in resource-limited settings.

Unlocking Immunity Within: Inflammatory Monocytes Stimulate T Cells at Immune Hubs in the Tumor Microenvironment.

A tighter grip on gene expression.

Engineered microRNA scaffolds for potent gene silencing in vivo.

ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA.

Regulation of somatic hypermutation by higher-order chromatin structure.

A Roadmap for Improving Reliability and Data Sharing in Crosslinking Mass Spectrometry.

Cohesin supercoils DNA during loop extrusion.

Developing a new cleavable crosslinker reagent for in-cell crosslinking.

Molecular basis of positional memory in limb regeneration.

Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage-defining transcription factor Foxp3.

Gastrulation: Lessons from the quail embryo.

Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence.

PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor.

Functional Lineage Tracing Using CaTCH.

ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213.

mTORC1 cooperates with tRNA wobble modification to sustain the protein synthesis machinery.

Conservation and divergence of the molecular regulators of the vertebrate fertilization synapse.

FakET: Simulating cryo-electron tomograms with neural style transfer.

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity.

TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases.

Author Correction: Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development.

Direct cell-to-cell transmission of retrotransposons.

Cold and hot fibrosis define clinically distinct cardiac pathologies.

Adeno-associated viruses for efficient gene expression in the axolotl nervous system.

Protein waste turned into antibiotics as a defence strategy of human cells.

Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.

Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis.

SMC motor proteins extrude DNA asymmetrically and can switch directions.

The UBR Domain of Plant Ubr1 Homolog PRT6 Accommodates Basic and Hydrophobic Amino Termini for Substrate Recognition.

Cohesin positions the epigenetic reader Phf2 within the genome.

Enhancer cooperativity can compensate for loss of activity over large genomic distances.

Challenging the Astral mass analyzer to quantify up to 5,300 proteins per single cell at unseen accuracy to uncover cellular heterogeneity.

Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven Cancers.

A Multiyear Longitudinal Harmonization Study of Quality Controls in Mass Spectrometry Proteomics Core Facilities.

RANK drives structured intestinal epithelial expansion during pregnancy.

Point-spread-function engineering in MINFLUX: optimality of donut and half-moon excitation patterns.

Modelling and deciphering tumour metabolism in CRISPR screens.

Proteome-wide non-cleavable crosslink identification with MS Annika 3.0 reveals the structure of the C. elegans Box C/D complex.

CRISPR-StAR enables high-resolution genetic screening in complex in vivo models.

Bouncer’s receptor on sperm: Investigating sperm-egg compatibility in fish

All eukaryotic SMC proteins induce a twist of -0.6 at each DNA loop extrusion step.

A conserved fertilization complex bridges sperm and egg in vertebrates.

A genome-wide screen identifies silencers with distinct chromatin properties and mechanisms of repression.

PITHD1: An Endogenous Inhibitor of the 26S Proteasome During Cellular Dormancy

A multivalent adaptor mechanism drives the nuclear import of proteasomes

PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor

Lineage tracing of Shh+ floor plate cells and dynamics of dorsal-ventral gene expression in the regenerating axolotl spinal cord.

Developmental and housekeeping transcriptional programs display distinct modes of enhancer-enhancer cooperativity in Drosophila.

Murine neonatal cardiac regeneration depends on Insulin-like growth factor 1 receptor signaling.

mTOR activity paces human blastocyst stage developmental progression.

A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids.

Friendly fire: recognition of self by the innate immune system.

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development.

A dual ribosomal system in the zebrafish soma and germline

Egr1 regulates regenerative senescence and cardiac repair.

Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape

A chromatin code for limb segment identity in axolotl limb regeneration.

Identification of Pathogenic Pathways for Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation.

Mechanism for the initiation of spliceosome disassembly.

Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition.

UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome.

Suppression of toxic transgene expression by optimized artificial miRNAs increases AAV vector yields in HEK-293 cells.

Rational correction of pathogenic conformational defects in HTRA1.

Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals.

tRNA expression and modification landscapes, and their dynamics during zebrafish embryo development.

Proteome-scale tagging and functional screening in mammalian cells by ORFtag.

Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.

Label-Free Sample Preparation for Single-Cell Proteomics.

Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types.

Red2Flpe-SCON: a versatile, multicolor strategy for generating mosaic conditional knockout mice.

Genomic surveillance of SARS-CoV-2 evolution by a centralised pipeline and weekly focused sequencing, Austria, January 2021 to March 2023.

ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum.

Sororin is an evolutionary conserved antagonist of WAPL.

TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligases

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity

Multiple ubiquitin ligases protect human genome integrity by targeting cancer-associated APOBEC3 deaminases for degradation

Structural basis of human U5 snRNP late biogenesis and recycling.

A molecular switch orchestrates the nuclear export of human messenger RNA

Tumor necrosis factor α promotes clonal dominance of KIT D816V+ cells in mastocytosis: role of survivin and impact on prognosis.

The molecular mechanisms underpinning maternal mRNA dormancy.

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria.

CowScape: Quantitative reconstruction of the conformational landscape of biological macromolecules from cryo-EM data

Pulling the strings on solid-to-liquid phase transitions in cell collectives.

Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism.

Targeted design of synthetic enhancers for selected tissues in the Drosophila embryo.

Micropillar arrays, wide window acquisition and AI-based data analysis improve comprehensiveness in multiple proteomic applications.

eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs.

Cancer Evolution: A Multifaceted Affair.

Morphogenesis and development of human telencephalic organoids in the absence and presence of exogenous extracellular matrix.

Cohesin and CTCF do not assemble TADs in Xenopus sperm and male pronuclei.

A High-Sensitivity Low-Nanoflow LC-MS Configuration for High-Throughput Sample-Limited Proteomics.

Immunopeptidomics in the Era of Single-Cell Proteomics.

In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids.

Multi-chamber cardioids unravel human heart development and cardiac defects.

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).

How do molecular motors fold the genome?

How embryos sort themselves out.

An automated nanowell-array workflow for quantitative multiplexed single-cell proteomics sample preparation at high sensitivity.

CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax.

SLAMseq resolves the kinetics of maternal and zygotic gene expression during early zebrafish embryogenesis.

The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG.

Improving single cell proteomics experiments: how can we best utilize latest-generation data acquisition and MS instrument architecture?

ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia.

Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development.

Single-cell brain organoid screening identifies developmental defects in autism.

SPOP targets the immune transcription factor IRF1 for proteasomal degradation.

Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths.

Evolutionary conservation of embryonic DNA methylome remodelling in distantly related teleost species.

Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms.

Transposon waves at the water-to-land transition.

Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.

MS Annika 2.0 Identifies Cross-Linked Peptides in MS2-MS3-Based Workflows at High Sensitivity and Specificity.

Precision RNAi using synthetic shRNAmir target sites.

Enhancers of the PAIR4 regulatory module promote distal VH gene recombination at the Igh locus.

Cooperation between bHLH transcription factors and histones for DNA access.

Widespread regulatory specificities between transcriptional co-repressors and enhancers in Drosophila.

Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase.

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses.

A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans.

Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries.

Testing pseudotopological and nontopological models for SMC-driven DNA loop extrusion against roadblock-traversal experiments.

An unbiased AAV-STARR-seq screen revealing the enhancer activity map of genomic regions in the mouse brain in vivo.

Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.

CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion.

Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells.

Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses.

Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.

mRNA recognition and packaging by the human transcription-export complex.

Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns.

SPOC domain proteins in health and disease.

Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids.

PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.

Enhancers display constrained sequence flexibility and context-specific modulation of motif function.

Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.

A hydraulic feedback loop between mesendoderm cell migration and interstitial fluid relocalization promotes embryonic axis formation in zebrafish.

TurboID-based proteomic profiling of meiotic chromosome axes in Arabidopsis thaliana.

Transcription shapes 3D chromatin organization by interacting with loop extrusion.

MYC determines lineage commitment in kras driven primary liver cancer development.

Effector-Triggered Immunity.

Robust and Easy-to-Use One-Pot Workflow for Label-Free Single-Cell Proteomics.

A de novo transcription-dependent TAD boundary underpins critical multiway interactions during antibody class switch recombination.

Label-free single cell proteomics utilizing ultrafast LC and MS instrumentation: A valuable complementary technique to multiplexing.

Topological morphogenesis of neuroepithelial organoids.

Generating human blastoids modeling blastocyst-stage embryos and implantation.

Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy.

SBNO2 is a critical mediator of STAT3-driven hematological malignancies.

EVI1 drives leukemogenesis through aberrant ERG activation.

MS Ana: Improving Sensitivity in Peptide Identification with Spectral Library Search.

Systematic identification and characterization of repressive domains in Drosophila transcription factors.

X-linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL.

A molecular network of conserved factors keeps ribosomes dormant in the egg.

Reply to: Assessment of 3D MINFLUX data for quantitative structural biology in cells.

StarMap: a user-friendly workflow for Rosetta-driven molecular structure refinement.

Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies.

Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM.

Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell-like Program Conserved in HPV-Positive Cancers.

ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers.

Correction: Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.

Chromosome Conformation Capture for Large Genomes.

Artificial Insemination in Axolotl.

Ethyl Cinnamate-Based Tissue Clearing Strategies.

Navigation and Use of Custom Tracks within the Axolotl Genome Browser.

Baculovirus Production and Infection in Axolotls.

Now that We Got There, What Next?

The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells.

SCON-a Short Conditional intrON for conditional knockout with one-step zygote injection.

Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration.

Deep Proteome Profiling with Reduced Carryover Using Superficially Porous Microfabricated nanoLC Columns.

The HUSH complex controls brain architecture and protocadherin fidelity.

DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions.

Different Gene Sets Are Associated With Azacitidine Response In Vitro Versus in Myelodysplastic Syndrome Patients.

Muscles are barely required for the patterning and cell dynamics in axolotl limb regeneration.

Sororin is an evolutionary conserved antagonist of WAPL

SMC complexes can traverse physical roadblocks bigger than their ring size.

Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers.

Deep Single-Shot NanoLC-MS Proteome Profiling with a 1500 Bar UHPLC System, Long Fully Porous Columns, and HRAM MS.

Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins.

Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development.

A self-generated Toddler gradient guides mesodermal cell migration.

Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.

Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury.

Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations.

Single-cell analyses of axolotl telencephalon organization, neurogenesis, and regeneration.

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation.

Structural basis of mRNA maturation: Time to put it together.

BRD4 degradation blocks expression of MYC and multiple forms of stem cell resistance in Ph+ chronic myeloid leukemia.

Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.

Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets.

Mechanism-based combination therapies for metastatic cancer.

Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling.

The specialist in regeneration-the Axolotl-a suitable model to study bone healing?

Mimicked synthetic ribosomal protein complex for benchmarking crosslinking mass spectrometry workflows.

Inducible and tissue-specific cell labeling in Cre-ERT2 transgenic Xenopus lines.

BacPROTACs mediate targeted protein degradation in bacteria.

Positional Memory in Vertebrate Regeneration: A Century's Insights from the Salamander Limb.

Nucleome programming is required for the foundation of totipotency in mammalian germline development.

Differential cofactor dependencies define distinct types of human enhancers.

Gene and transgenics nomenclature for the laboratory axolotl-Ambystoma mexicanum.

Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration.

Moyamoya disease: diagnosis and interventions.

Cryo-EM structure of the plant 26S proteasome.

DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of synthetic enhancers.

MCM complexes are barriers that restrict cohesin-mediated loop extrusion.

Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report.

Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A.

An allosteric HTRA1-calpain 2 complex with restricted activation profile.

Cornelia de Lange syndrome mutations in NIPBL can impair cohesin-mediated DNA loop extrusion.

The Axolotl's journey to the modern molecular era.

NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation.

A Rapid, Highly Sensitive and Open-Access SARS-CoV-2 Detection Assay for Laboratory and Home Testing.

Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease.

Tig1 regulates proximo-distal identity during salamander limb regeneration.

Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.

The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation.

Interferons reshape the 3D conformation and accessibility of macrophage chromatin.

Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.

Proteome-scale identification of transcriptional activators in human cells.

Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families.

Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis.

Amplification of human interneuron progenitors promotes brain tumors and neurological defects.

The Sperm Protein Spaca6 is Essential for Fertilization in Zebrafish.

Somatic hypermutation spectra are independent of the local transcriptional and epigenetic landscape

Cross-Modality Imaging of Murine Tumor Vasculature-a Feasibility Study.

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma.

Quantitative Accuracy and Precision in Multiplexed Single-Cell Proteomics.

Human blastoids model blastocyst development and implantation.

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.

MS Amanda 2.0: Advancements in the standalone implementation.

Targeting CD56 with an antibody-drug conjugate in Merkel cell carcinoma.

AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

Comparative proteome signatures of trace samples by multiplexed Data-Independent Acquisition.

Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis.

Results of WICOVIR Gargle Pool PCR Testing in German Schools Based on the First 100,000 Tests.

The cellular and signaling dynamics of salamander limb regeneration.

Cohesin mediates DNA loop extrusion by a "swing and clamp" mechanism.

Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.

Maternally-inherited anti-sense piRNAs antagonize transposon expression in teleost embryos

Reciprocal zebrafish-medaka hybrids reveal maternal control of zygotic genome activation timing

Correction to: Cross-Modality Imaging of Murine Tumor Vasculature-a Feasibility Study.

The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains.

miR-1 sustains muscle physiology by controlling V-ATPase complex assembly.

Cdc4 phospho-degrons allow differential regulation of Ame1CENP-U protein stability across the cell cycle.

Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter.

The expression, localisation and interactome of pigeon CRY2.

The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization.

Structure of the peripheral arm of a minimalistic respiratory complex I.

Prevalence of RT-qPCR-detected SARS-CoV-2 infection at schools: First results from the Austrian School-SARS-CoV-2 prospective cohort study.

GSK3-mediated phosphorylation of DEK3 regulates chromatin accessibility and stress tolerance in Arabidopsis.

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.

Sensitivity and specificity of the antigen-based anterior nasal self-testing programme for detecting SARS-CoV-2 infection in schools, Austria, March 2021.

Gaze mechanisms enabling the detection of faint stars in the night sky.

Insights into gene regulation: From regulatory genomic elements to DNA-protein and protein-protein interactions.

How DNA loop extrusion mediated by cohesin enables V(D)J recombination.

Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response.

MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells.

Concepts and functions of small RNA pathways in C. elegans.

Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.

Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics.

Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly.

Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development.

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.

A new society for regenerative biologists.

Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex.

The Fertilization Enigma: How Sperm and Egg Fuse.

Ultrasensitive NanoLC-MS of Subnanogram Protein Samples Using Second Generation Micropillar Array LC Technology with Orbitrap Exploris 480 and FAIMS PRO.

The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma

Down-regulation of A20 promotes immune escape of lung adenocarcinomas.

Toward whole tissue imaging of axolotl regeneration.

Systematic refinement of gene annotations by parsing mRNA 3' end sequencing datasets.

Quality standards in proteomics research facilities: Common standards and quality procedures are essential for proteomics facilities and their users.

A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells.

Genome folding through loop extrusion by SMC complexes.

Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.

Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.

Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition.

Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration.

MS Annika: A New Cross-Linking Search Engine.

Cleavable Cross-Linkers and Mass Spectrometry for the Ultimate Task of Profiling Protein-Protein Interaction Networks in Vivo.

Cardioids reveal self-organizing principles of human cardiogenesis.

Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq.

Cellular Control of Protein Turnover via the Modification of the Amino Terminus.

DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations

A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.

Metabolic regulation by PPARγ is required for IL-33-mediated activation of ILC2s in lung and adipose tissue.

Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation.

Central amygdala circuit dynamics underlying the benzodiazepine anxiolytic effect.

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

Fibroblast dedifferentiation as a determinant of successful regeneration.

Visualization of loop extrusion by DNA nanoscale tracing in single human cells

Self-organized cell migration across scales - from single cell movement to tissue formation.

Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation.

Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex.

The giant axolotl genome uncovers the evolution, scaling, and transcriptional control of complex gene loci.

Giant lungfish genome elucidates the conquest of land by vertebrates.

Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters.

Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions.

Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters.

RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy.

Head-to-head comparison of direct-input RT-PCR and RT-LAMP against RT-qPCR on extracted RNA for rapid SARS-CoV-2 diagnostics.

Angelika Amon (1967-2020).

A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.

LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma.

Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition.

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.

A versatile depigmentation, clearing, and labeling method for exploring nervous system diversity.

Unsupervised learning of control signals and their encodings in Caenorhabditis elegans whole-brain recordings.

Neuronal circuits and the magnetic sense: central questions.

AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes.

Fast and Highly Efficient Affinity Enrichment of Azide-A-DSBSO Cross-Linked Peptides.

Two MicroRNAs Are Sufficient for Embryonic Patterning in C. elegans.

SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells.

Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers.

Why (and how) we should publish negative data.

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL.

Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.

Structure of the human core transcription-export complex reveals a hub for multivalent interactions.

Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe.

The amygdala instructs insular feedback for affective learning.

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress.

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1.

Combinatorial Action of Temporally Segregated Transcription Factors.

Repression of the B cell identity factor Pax5 is not required for plasma cell development.

DigiTAG-a RNA Sequencing Approach to Analyze Transcriptomes of Rare Cell Populations in Drosophila melanogaster.

CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia.

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.

MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium.

Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration.

A Human Retinal Pigment Epithelium-Based Screening Platform Reveals Inducers of Photoreceptor Outer Segments Phagocytosis.

Oral and Palatal Dentition of Axolotl Arises From a Common Tooth-Competent Zone Along the Ecto-Endodermal Boundary.

Brain-wide representations of ongoing behavior: a universal principle?

Introducing www.axolotl-omics.org - an integrated -omics data portal for the axolotl research community.

Structure-function analysis of microRNA 3'-end trimming by Nibbler.

A human tissue screen identifies a regulator of ER secretion as a brain-size determinant.

Conformation of sister chromatids in the replicated human genome.

A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse.

Identification of ALK in Thinness.

Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytes.

Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells.

Stress peptides sensitize fear circuitry to promote passive coping.

A high sensitivity ZENK monoclonal antibody to map neuronal activity in Aves.

HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.

The H3 histone chaperone NASPSIM3 escorts CenH3 in Arabidopsis.

Species-specific mechanisms during fertilization.

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming.

Correction: The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes.

Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin.

A Data Structure for Real-Time Aggregation Queries of Big Brain Networks.

Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles.

Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy.

MicroRNAs: From Mechanism to Organism.

ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.

PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion.

The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor.

Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse.

Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level.

Spt5-mediated enhancer transcription directly couples enhancer activation with physical promoter interaction.

Quantifying the heterogeneity of macromolecular machines by mass photometry.

A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes.

Activation by substoichiometric inhibition.

Nested Neuronal Dynamics Orchestrate a Behavioral Hierarchy across Timescales.

Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis.

Author Correction: Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling.

Allies or Enemies-The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment.

Improved Sensitivity in Low-Input Proteomics Using Micropillar Array-Based Chromatography.

A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates.

Structural analysis of urinary light chains and proteomic analysis of hyaline tubular casts in light chain associated kidney disorders.

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.

All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.

A Putative Mechanism for Magnetoreception by Electromagnetic Induction in the Pigeon Inner Ear.

Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast.

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.

A role for miR-132 in learned safety.

Spectral recording of gene expression history by fluorescent timer protein.

Shaping Striated Muscles with Ubiquitin Proteasome System in Health and Disease.

STARR-seq and UMI-STARR-seq: Assessing Enhancer Activities for Genome-Wide-, High-, and Low-Complexity Candidate Libraries.

Spectral Clustering Improves Label-Free Quantification of Low-Abundant Proteins.

Imaging the Emergence of Behavior.

Optimized Fragmentation Improves the Identification of Peptides Cross-Linked by MS-Cleavable Reagents.

Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy.

Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.

Self-organization of parS centromeres by the ParB CTP hydrolase.

Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells.

DNA loop extrusion by human cohesin.

Tinbergen's challenge for the neuroscience of behavior.

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.

Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.

The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts.

apQuant: Accurate Label-Free Quantification by Quality Filtering.

Volumetric Ca2+ Imaging in the Mouse Brain Using Hybrid Multiplexed Sculpted Light Microscopy.

Absolute quantification of cohesin, CTCF and their regulators in human cells.

A Comparative Perspective on Brain Regeneration in Amphibians and Teleost Fish.

The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.

Evolution of neuronal anatomy and circuitry in two highly divergent nematode species.

Functional-genetic approaches to understanding drug response and resistance.

A kinase-independent role for CDK8 in BCR-ABL1+ leukemia.

Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

N-terminal β-strand underpins biochemical specialization of an ATG8 isoform.

No evidence for a magnetite-based magnetoreceptor in the lagena of pigeons.

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity.

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.

Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.

Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism.

The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop.

The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes.

Estrogen Signaling Drives Ciliogenesis in Human Endometrial Organoids.

Sequencing cell-type-specific transcriptomes with SLAM-ITseq.

SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1.

Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.

Broad applicability of a streamlined ethyl cinnamate-based clearing procedure.

Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes.

Transcriptional cofactors display specificity for distinct types of core promoters.

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription.

The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells.

Structure of McsB, a protein kinase for regulated arginine phosphorylation.

Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination.

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.

Quantification of experimentally induced nucleotide conversions in high-throughput sequencing datasets.

Publisher Correction: Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).

Human blood vessel organoids as a model of diabetic vasculopathy.

Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute.

BrainTrawler: A visual analytics framework for iterative exploration of heterogeneous big brain data

Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling

Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Publisher Correction: Sequencing cell-type-specific transcriptomes with SLAM-ITseq.

Human tripartite motif protein 52 is required for cell context-dependent proliferation.

CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.

Ectopic otoconial formation in the lagena of the pigeon inner ear.

Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe.

Lidocaine is a nocebo treatment for trigeminally mediated magnetic orientation in birds.

TCEA1 regulates the proliferative potential of mouse myeloid cells.

Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta.

Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop.

Sensorimotor integration in Caenorhabditis elegans: a reappraisal towards dynamic and distributed computations.

Eukaryotic core promoters and the functional basis of transcription initiation.

CharmeRT: Boosting Peptide Identifications by Chimeric Spectra Identification and Retention Time Prediction.

CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis.

Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation.

Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.

Analysis of PNGase F-Resistant N-Glycopeptides Using SugarQb for Proteome Discoverer 2.1 Reveals Cryptic Substrate Specificities.

Energy Scarcity Promotes a Brain-wide Sleep State Modulated by Insulin Signaling in C. elegans.

Sensorimotor Integration for Decision Making: How the Worm Steers.

A Guide to Emerging Technologies for Large-Scale and Whole-Brain Optical Imaging of Neuronal Activity.

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Dorsal tegmental dopamine neurons gate associative learning of fear.

Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.

High-speed volumetric imaging of neuronal activity in freely moving rodents.

Dynamics of sister chromatid resolution during cell cycle progression.

Resolving systematic errors in widely used enhancer activity assays in human cells.

Epigenetic regulation of brain region-specific microglia clearance activity.

Cell-type specific sequencing of microRNAs from complex animal tissues.

Cryptochrome: The magnetosensor with a sinister side?

A high-throughput method to identify trans-activation domains within transcription factor sequences.

Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).

Structural prediction of protein models using distance restraints derived from cross-linking mass spectrometry data.

A new era of proactive melanoma therapy: hit hard, hit early.

The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion.

Reply to 'Defining distance restraints in HADDOCK'.

Necroptosis microenvironment directs lineage commitment in liver cancer.

Control of B-1a cell development by instructive BCR signaling.

Experimental and computational framework for a dynamic protein atlas of human cell division.

The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML.

Expressing Multi-subunit Complexes Using biGBac.

Comment on "Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans".

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.

Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells.

Prespliceosome structure provides insights into spliceosome assembly and regulation.

Pooled Generation of Lentiviral Tetracycline-Regulated microRNA Embedded Short Hairpin RNA Libraries.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation.

Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration.

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.

Analysis of chromosomes from mouse oocytes and mammalian cultured cells by light microscopy.

Predicting functional neuroanatomical maps from fusing brain networks with genetic information.

The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.

Improved Genome Assembly and Annotation for the Rock Pigeon (Columba livia).

A programmable platform for sub-second multichemical dynamic stimulation and neuronal functional imaging in C. elegans.

PhoStar: Identifying Tandem Mass Spectra of Phosphorylated Peptides before Database Search.

Affinity proteomics reveals extensive phosphorylation of the Brassica chromosome axis protein ASY1 and a network of associated proteins at prophase I of meiosis.

SLAM-ITseq: sequencing cell type-specific transcriptomes without cell sorting.

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis.

Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation.

An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.

The axolotl genome and the evolution of key tissue formation regulators.

Senescence-associated reprogramming promotes cancer stemness.

Regenerating tissues.

Pseudotyped baculovirus is an effective gene expression tool for studying molecular function during axolotl limb regeneration.

The IAP family member BRUCE regulates autophagosome-lysosome fusion.

UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.

Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation.

Author Correction: High-speed volumetric imaging of neuronal activity in freely moving rodents.

Author Correction: The axolotl genome and the evolution of key tissue formation regulators.

Author Correction: Structural prediction of protein models using distance restraints derived from cross-linking mass spectrometry data.

Publisher Correction: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.

Behavioral Assays to Study Oxygen and Carbon Dioxide Sensing in Caenorhabditis elegans.

Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes.

Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia.

R Loops in the Regulation of Antibody Gene Diversification.

Phosphoproteomics with Activated Ion Electron Transfer Dissociation.

Control of type III protein secretion using a minimal genetic system.

BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling.

Tubulins and brain development - The origins of functional specification.

Subcellular analysis of pigeon hair cells implicates vesicular trafficking in cuticulosome formation and maintenance.

Nodal patterning without Lefty inhibitory feedback is functional but fragile.

The crystal structure of Deg9 reveals a novel octameric-type HtrA protease.

Efficient gene knockin in axolotl and its use to test the role of satellite cells in limb regeneration.

Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations.

BIME2, a novel gene required for interhomolog meiotic recombination in the protist model organism Tetrahymena.

Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.

A vital sugar code for ricin toxicity.

An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries.

Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.

Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression.

Dissection of neuronal gap junction circuits that regulate social behavior in Caenorhabditis elegans.

Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.

Non-model model organisms.

Urinary neprilysin in the critically ill patient.

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.

Comparative glycoproteomics of stem cells identifies new players in ricin toxicity.

STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth.

Proceedings of the EuBIC Winter School 2017.

Reconstitution of a Patterned Neural Tube from Single Mouse Embryonic Stem Cells.

A global brain state underlies C. elegans sleep behavior.

A right-handed signalling pathway drives heart looping in vertebrates.

Is magnetogenetics the new optogenetics?

Combinatorial function of transcription factors and cofactors.

A mechanism of cohesin-dependent loop extrusion organizes zygotic genome architecture.

Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.

Salamander spinal cord regeneration: The ultimate positive control in vertebrate spinal cord regeneration.

CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens.

Thiol-linked alkylation of RNA to assess expression dynamics.

Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.

Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.

RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1.

Magnetoreception-A sense without a receptor.

Promoting transcription over long distances.

Root diffusion barrier control by a vasculature-derived peptide binding to the SGN3 receptor.

Virtual reality for freely moving animals.

A framework for understanding the roles of miRNAs in animal development.

A Zip3-like protein plays a role in crossover formation in the SC-less meiosis of the protist Tetrahymena.

Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability.

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.

DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes.

CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis.

Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy.

Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl.

Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.

Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia.

Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells.

Prediction of potent shRNAs with a sequential classification algorithm.

Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution.

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.

Probing the canonicity of the Wnt/Wingless signaling pathway.

Activation of an exonic splice-donor site in exon 30 of CDK5RAP2 in a patient with severe microcephaly and pigmentary abnormalities.

RNA-binding profiles of Drosophila CPEB proteins Orb and Orb2.

MuSK Kinase Activity is Modulated By A Serine Phosphorylation Site in The Kinase Loop.

Correction to "Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2-MND1".

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis.

Chemical Biology Interrogates Protein Arginine Phosphorylation.

Editorial overview: Cell reprogramming, regeneration and repair.

Topology and structure of an engineered human cohesin complex bound to Pds5B.

Direct detection of a single photon by humans.

Gene Regulation: Activation through Space.

MEK1 is required for the development of NRAS-driven leukemia.

Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6-Bre1.

RANKL/RANK control Brca1 mutation- .

CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the Kinetochore.

Automatic Segmentation of Drosophila Neural Compartments Using GAL4 Expression Data Reveals Novel Visual Pathways.

A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function.

Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach.

DNA Replication Origins in Immunoglobulin Switch Regions Regulate Class Switch Recombination in an R-Loop-Dependent Manner.

Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.

Regulation of two motor patterns enables the gradual adjustment of locomotion strategy in Caenorhabditis elegans.

Regulatory Enhancer-Core-Promoter Communication via Transcription Factors and Cofactors.

Structural basis for the disaggregase activity and regulation of Hsp104.

Molecular basis of outer kinetochore assembly on CENP-T.

De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation.

Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.

Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.

β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis.

Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells.

PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia.

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.

An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS.

Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation.

SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation.

Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development.

Rapid movement and transcriptional re-localization of human cohesin on DNA.

A de novo frameshift in HNRNPK causing a Kabuki-like syndrome with nodular heterotopia.

Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila.

Neuron type-specific miRNA represses two broadly expressed genes to modulate an avoidance behavior in C. elegans.

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer.

Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus.

CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.

Fast volumetric calcium imaging across multiple cortical layers using sculpted light.

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.

Decoding sORF translation - from small proteins to gene regulation.

The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.

Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation.

Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia.

Arginine phosphorylation marks proteins for degradation by a Clp protease.

A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle Formation.

Adaptive and Background-Aware GAL4 Expression Enhancement of Co-registered Confocal Microscopy Images.

Mechanism of APC/CCDC20 activation by mitotic phosphorylation.

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client.

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes.

Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine.

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

Oxygen-induced social behaviours in Pristionchus pacificus have a distinct evolutionary history and genetic regulation from Caenorhabditis elegans.

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.

C. elegans Body Cavity Neurons Are Homeostatic Sensors that Integrate Fluctuations in Oxygen Availability and Internal Nutrient Reserves.

Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia.

ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores.

Sororin actively maintains sister chromatid cohesion.

Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.

Deletions and de novo mutations of SOX11 are associated with a neurodevelopmental disorder with features of Coffin-Siris syndrome.

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation.

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response.

NK Cell-Specific Gata3 Ablation Identifies the Maturation Program Required for Bone Marrow Exit and Control of Proliferation.

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes.

Measuring APC/C-Dependent Ubiquitylation In Vitro.

Polysialylation controls dendritic cell trafficking by regulating chemokine recognition.

Burst muscle performance predicts the speed, acceleration, and turning performance of Anna's hummingbirds.

Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration.

Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2-MND1.

Mutations in PIGY: expanding the phenotype of inherited glycosylphosphatidylinositol deficiencies.

Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish.

The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.

Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals.

The Expression of Tubb2b Undergoes a Developmental Transition in Murine Cortical Neurons.

STARR-seq - principles and applications.

Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis.

Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.

The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception.

Arabidopsis PCH2 Mediates Meiotic Chromosome Remodeling and Maturation of Crossovers.

Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation.

Synaptic Orb2A Bridges Memory Acquisition and Late Memory Consolidation in Drosophila.

Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.

Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia.

MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells.

G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.

Spatial Regulation of V-(D)J Recombination at Antigen Receptor Loci.

Global brain dynamics embed the motor command sequence of Caenorhabditis elegans.

Visualizing KcsA conformational changes upon ion binding by infrared spectroscopy and atomistic modeling.

Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

The histone chaperone CAF-1 safeguards somatic cell identity.

Transcriptional regulators form diverse groups with context-dependent regulatory functions.

Coordinating the human looks.

Anion-exchange chromatography of phosphopeptides: weak anion exchange versus strong anion exchange and anion-exchange chromatography versus electrostatic repulsion-hydrophilic interaction chromatography.

Laser-induced acoustic desorption of natural and functionalized biochromophores.

Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

Predicting the Dynamics of Network Connectivity in the Neocortex.

Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3.

Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana.

High-efficiency electroporation of the spinal cord in larval axolotl.

Transgenesis in axolotl (Ambystoma mexicanum).

The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression.

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.

Pillars Article: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999. 401: 556-562.

The RNA-binding protein Arrest (Bruno) regulates alternative splicing to enable myofibril maturation in Drosophila flight muscle.

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.

Direct and indirect targeting of MYC to treat acute myeloid leukemia.

Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia.

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3.

Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.

3DSpectra: A 3-dimensional quantification algorithm for LC-MS labeled profile data.

Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern.

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.

Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.

Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement.

Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.

No evidence for intracellular magnetite in putative vertebrate magnetoreceptors identified by magnetic screening.

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation.

Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.

Optimizing and extending light-sculpting microscopy for fast functional imaging in neuroscience.

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation.

Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.

An inducible retroviral expression system for tandem affinity purification mass-spectrometry-based proteomics identifies MLKL as an HSP90 client.

Germline Transgenic Methods for Tracking Cells and Testing Gene Function during Regeneration in the Axolotl.

Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap.

NDST1 missense mutations in autosomal recessive intellectual disability.

Development of siRNA payloads to target KRAS-mutant cancer.

Versatile in vitro system to study translocation and functional integration of bacterial outer membrane proteins.

A dual role for autophagy in a murine model of lung cancer.

3D reconstitution of the patterned neural tube from embryonic stem cells.

A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis.

Arabidopsis PIAL1 and 2 promote SUMO chain formation as E4-type SUMO ligases and are involved in stress responses and sulfur metabolism.

Asymmetric processing of visual motion for simultaneous object and background responses.

H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress.

The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.

Msh4 and Msh5 function in SC-independent chiasma formation during the streamlined meiosis of Tetrahymena.

Deep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation.

Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation.

Cellular and molecular basis of decision-making.

CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration.

TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons.

Alternative 3' UTR selection controls PAR-5 homeostasis and cell polarity in C. elegans embryos.

"Uno, nessuno e centomila": the different faces of the budding yeast kinetochore.

Diversity and wiring variability of visual local neurons in the Drosophila medulla M6 stratum.

Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells.

Development and performance evaluation of an ultralow flow nanoliquid chromatography-tandem mass spectrometry set-up.

BRD4: a BET(ter) target for the treatment of AML?

Epigenetic targeting of activation-induced cytidine deaminase.

The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes.

qcML: an exchange format for quality control metrics from mass spectrometry experiments.

Global analysis of muscle-specific kinase signaling by quantitative phosphoproteomics.

MS Amanda, a universal identification algorithm optimized for high accuracy tandem mass spectra.

Preclinical efficacy of MEK inhibition in Nras-mutant AML.

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

Dissection of thousands of cell type-specific enhancers identifies dinucleotide repeat motifs as general enhancer features.

SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.

Automated image-based tracking and its application in ecology.

Modeling human development in 3D culture.

ZRF1 controls the retinoic acid pathway and regulates leukemogenic potential in acute myeloid leukemia.

Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense.

Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species.

Is salamander limb regeneration really perfect? Anatomical and morphogenetic analysis of forelimb muscle regeneration in GFP-transgenic axolotls as a basis for regenerative, developmental, and evolutionary studies.

Epigenetic control of immunity.

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

Myosin chaperones.

Characterization of a DNA exit gate in the human cohesin ring.

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Measuring the functional organization of the neocortex at large and small scales.

Central amygdala PKC-δ(+) neurons mediate the influence of multiple anorexigenic signals.

A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A.

Is salamander hindlimb regeneration similar to that of the forelimb? Anatomical and morphogenetic analysis of hindlimb muscle regeneration in GFP-transgenic axolotls as a basis for regenerative and developmental studies.

Genomics: Hiding in plain sight.

Mathematical modeling of regenerative processes.

Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation.

Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response.

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.

Genome-scale functional characterization of Drosophila developmental enhancers in vivo.

Optimized axolotl (Ambystoma mexicanum) husbandry, breeding, metamorphosis, transgenesis and tamoxifen-mediated recombination.

Development of fore- and hindlimb muscles in GFP-transgenic axolotls: morphogenesis, the tetrapod bauplan, and new insights on the forelimb-hindlimb enigma.

Neural circuit components of the Drosophila OFF motion vision pathway.

Quantitative genome-wide enhancer activity maps for five Drosophila species show functional enhancer conservation and turnover during cis-regulatory evolution.

FlyMAD: rapid thermogenetic control of neuronal activity in freely walking Drosophila.

Ascending SAG neurons control sexual receptivity of Drosophila females.

RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1.

Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy.

Cellular and behavioral functions of fruitless isoforms in Drosophila courtship.

Electron tomography and simulation of baculovirus actin comet tails support a tethered filament model of pathogen propulsion.

cis-regulatory requirements for tissue-specific programs of the circadian clock.

Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids.

Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors.

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.

Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.

Flying Drosophila stabilize their vision-based velocity controller by sensing wind with their antennae.

Hormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin.

Transcriptional enhancers: from properties to genome-wide predictions.

Differential requirement for Nfil3 during NK cell development.

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.

Stage-specific control of early B cell development by the transcription factor Ikaros.

Neuronal control of Drosophila walking direction.

Microtubules and neurodevelopmental disease: the movers and the makers.

Mutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation.

Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins.

A conserved role for Snail as a potentiator of active transcription.

Structure of a pathogenic type 3 secretion system in action.

Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1.

Reverse Engineering Animal Vision with Virtual Reality and Genetics.

Regulatory Genomics - Decoding Drosophila Regulatory Sequences.

Transcriptome and proteome quantification of a tumor model provides novel insights into post-transcriptional gene regulation.

Control of antigen receptor diversity through spatial regulation of V(D)J recombination.

An optimized microRNA backbone for effective single-copy RNAi.

Circadian and circalunar clock interactions in a marine annelid.

Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain.

Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria.

Identification of transcription factor binding sites from ChIP-seq data at high resolution.

Protein-mediated transformation of lipid vesicles into tubular networks.

Limb regeneration.

Multiple mechanisms contribute to centriole separation in C. elegans.

Spectrally coded optical nanosectioning (SpecON) with biocompatible metal-dielectric-coated substrates.

Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program.

Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain.

Optimized nonlinear gradients for reversed-phase liquid chromatography in shotgun proteomics.

A multiplicative reinforcement learning model capturing learning dynamics and interindividual variability in mice.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Co-expression of VAL- and TMT-opsins uncovers ancient photosensory interneurons and motorneurons in the vertebrate brain.

CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis.

Periventricular heterotopia in 6q terminal deletion syndrome: role of the C6orf70 gene.

Dynamics of dendritic spines in the mouse auditory cortex during memory formation and memory recall.

Progressive specification rather than intercalation of segments during limb regeneration.

Deciphering the transcriptional cis-regulatory code.

Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans.

A comprehensive wiring diagram of the protocerebral bridge for visual information processing in the Drosophila brain.

An iron-rich organelle in the cuticular plate of avian hair cells.

Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light.

Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components.

Transgenic mouse models enabling photolabeling of individual neurons in vivo.

Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells.

Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin.

Comparative RNA-seq analysis in the unsequenced axolotl: the oncogene burst highlights early gene expression in the blastema.

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis.

Wapl is an essential regulator of chromatin structure and chromosome segregation.

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Discriminating external and internal causes for heading changes in freely flying Drosophila.

Foamy virus for efficient gene transfer in regeneration studies.

GABAergic neurons regulate lateral ventricular development via transcription factor Pax5.

Analysis of meiotic protein complexes from Arabidopsis and Brassica using affinity-based proteomics.

Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.

Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium.

Studying the fragmentation behavior of peptides with arginine phosphorylation and its influence on phospho-site localization.

Interlaboratory studies and initiatives developing standards for proteomics.

Unambiguous phosphosite localization using electron-transfer/higher-energy collision dissociation (EThcD).

A directional tuning map of Drosophila elementary motion detectors.

High resolution anatomical mapping confirms the absence of a magnetic sense system in the rostral upper beak of pigeons.

Life(span) in balance: oxygen fuels a sophisticated neural network for lifespan homeostasis in C. elegans.

Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation.

EGL-13/SoxD specifies distinct O2 and CO2 sensory neuron fates in Caenorhabditis elegans.

Parallel neural pathways mediate CO2 avoidance responses in Drosophila.

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.

Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes.

CLP1 links tRNA metabolism to progressive motor-neuron loss.

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

Yeast protein phosphatase 2A-Cdc55 regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 chromatin recruitment.

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors.

The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.

Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl.

Genome-wide quantitative enhancer activity maps identified by STARR-seq.

Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation.

Molecular requirements for the formation of a kinetochore-microtubule interface by Dam1 and Ndc80 complexes.

Muscle and connective tissue progenitor populations show distinct Twist1 and Twist3 expression profiles during axolotl limb regeneration.

Drosophila Embryo Stage Annotation using Label Propagation

The non-redundant function of cohesin acetyltransferase Esco2: some answers and new questions.

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.

Neural crest does not contribute to the neck and shoulder in the axolotl (Ambystoma mexicanum).

Stem cells in the land of the rising sun: ISSCR 2012.

Reprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins.

Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.

A histone deacetylase adjusts transcription kinetics at coding sequences during Candida albicans morphogenesis.

Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.

SIMPATIQCO: a server-based software suite which facilitates monitoring the time course of LC-MS performance metrics on Orbitrap instruments.

Sister chromatid cohesion.

Regeneration and reprogramming.

Anatomy of the pectoral and forelimb muscles of wildtype and green fluorescent protein-transgenic axolotls and comparison with other tetrapods including humans: a basis for regenerative, evolutionary and developmental studies.

Reconstitution of the central nervous system during salamander tail regeneration from the implanted neurospheres.

The Drosophila female aphrodisiac pheromone activates ppk23(+) sensory neurons to elicit male courtship behavior.

FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal.

A novel nonsense CDK5RAP2 mutation in a Somali child with primary microcephaly and sensorineural hearing loss.

Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding.

Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis.

Seventy-five genetic loci influencing the human red blood cell.

Cancer stem cell definitions and terminology: the devil is in the details.

NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma.

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

Analysis of protein mixtures from whole-cell extracts by single-run nanoLC-MS/MS using ultralong gradients.

The Arabidopsis HEI10 is a new ZMM protein related to Zip3.

Drosophila CPEB Orb2A mediates memory independent of Its RNA-binding domain.

Discrete neocortical dynamics predict behavioral categorization of sounds.

The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells.

Actin branching in the initiation and maintenance of lamellipodia.

Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing.

A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells.

A pipeline for the generation of shRNA transgenic mice.

Regenerative biology: Skin, heal thyself.

Reconstitution of the central and peripheral nervous system during salamander tail regeneration.

Dopamine neurons modulate pheromone responses in Drosophila courtship learning.

Update on sumoylation: defining core components of the plant SUMO conjugation system by phylogenetic comparison.

Diversity and roles of (t)RNA ligases.

Regulation of DNA replication within the immunoglobulin heavy-chain locus during B cell commitment.

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis.

Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylation.

Induction of immediate early genes in the mouse auditory cortex after auditory cued fear conditioning to complex sounds.

Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.

CENP-T proteins are conserved centromere receptors of the Ndc80 complex.

Centrosomes can initiate a polarity axis from any position within one-cell C. elegans embryos.

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.

Induced heterodimerization and purification of two target proteins by a synthetic coiled-coil tag.

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.

Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression.

HOT regions function as patterned developmental enhancers and have a distinct cis-regulatory signature.

The blueprint of the type-3 injectisome.

The many functions of cohesin--different rings to rule them all?

Inter-homolog crossing-over and synapsis in Arabidopsis meiosis are dependent on the chromosome axis protein AtASY3.

Reshaping the optical dimension in optogenetics.

Essential role of EBF1 in the generation and function of distinct mature B cell types.

Clusters of iron-rich cells in the upper beak of pigeons are macrophages not magnetosensitive neurons.

Exome sequencing can detect pathogenic mosaic mutations present at low allele frequencies.

WNTing embryonic stem cells.

Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin.

Methods in cell biology: analysis of cell polarity in C. elegans embryos.

Auditory circuit in the Drosophila brain.

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ.

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia.

A computational pipeline for comparative ChIP-seq analyses.

Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.

An RNA-Seq strategy to detect the complete coding and non-coding transcriptome including full-length imprinted macro ncRNAs.

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

Universal and confident phosphorylation site localization using phosphoRS.

Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome.

Systematic phosphorylation analysis of human mitotic protein complexes.

Limb regeneration: a new development?

Spalt mediates an evolutionarily conserved switch to fibrillar muscle fate in insects.

Modification of the conformational skin structure by treatment with liposomal formulations and its correlation to the penetration depth of aciclovir.

Cytoarchitectural disruption of the superior colliculus and an enlarged acoustic startle response in the Tuba1a mutant mouse.

Activation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component.

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.

A high-resolution map of human evolutionary constraint using 29 mammals.

Pax5: a master regulator of B cell development and leukemogenesis.

Protein quality control in the bacterial periplasm.

A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.

Gene expression profile of the regeneration epithelium during axolotl limb regeneration.

Neural-specific elongation of 3' UTRs during Drosophila development.

Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.

A system for imaging the regulatory noncoding Xist RNA in living mouse embryonic stem cells.

Interstitial lung disease induced by gefitinib and toll-like receptor ligands is mediated by Fra-1.

GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis.

CTCF-binding elements mediate control of V(D)J recombination.

Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.

General statistical modeling of data from protein relative expression isobaric tags.

Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.

Immersion freezing of biological specimens: rationale, principles, and instrumentation.

The cellular basis for animal regeneration.

Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.

A blueprint for kinetochores - new insights into the molecular mechanics of cell division.

Altered Mascot search results by changing the m/z range of MS/MS spectra: analysis and potential applications.

Comment on 'Jobs for the boys'.

Multiplicative dynamics underlie the emergence of the log-normal distribution of spine sizes in the neocortex in vivo.

Random mutagenesis of the prokaryotic peptide transporter YdgR identifies potential periplasmic gating residues.

Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation.

Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis.

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells.

Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance.

Ultra-high-pressure RPLC hyphenated to an LTQ-Orbitrap Velos reveals a linear relation between peak capacity and number of identified peptides.

Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails.

EMCD real space maps of Magnetospirillum magnetotacticum.

Robo-3--mediated repulsive interactions guide R8 axons during Drosophila visual system development.

Distinct and conserved prominin-1/CD133-positive retinal cell populations identified across species.

High conservation of transcription factor binding and evidence for combinatorial regulation across six Drosophila species.

Quality control in LC-MS/MS.

Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads.

Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure.

Regulation of GATA-3 expression during CD4 lineage differentiation.

Confined activation and subdiffractive localization enables whole-cell PALM with genetically expressed probes.

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells.

Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis.

Improved precision of iTRAQ and TMT quantification by an axial extraction field in an Orbitrap HCD cell.

Functional identification of optimized RNAi triggers using a massively parallel sensor assay.

Substrate-induced remodeling of the active site regulates human HTRA1 activity.

The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells.

Epigenetic regulation of learning and memory by Drosophila EHMT/G9a.

Entry of a heparan sulphate-binding HRV8 variant strictly depends on dynamin but not on clathrin, caveolin, and flotillin.

Neuronal control of Drosophila courtship song.

Augmenting β-augmentation: structural basis of how BamB binds BamA and may support folding of outer membrane proteins.

Flybow: genetic multicolor cell labeling for neural circuit analysis in Drosophila melanogaster.

HTRA proteases: regulated proteolysis in protein quality control.

Three-dimensional model of Salmonella's needle complex at subnanometer resolution.

Membrane lipidome of an epithelial cell line.

HSPC117 is the essential subunit of a human tRNA splicing ligase complex.

Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex.

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.

X Inactivation and Progenitor Cancer Cells

Vibrational excitons in ionophores: experimental probes for quantum coherence-assisted ion transport and selectivity in ion channels

Using MATLAB to Achieve Nanoscale Optical Sectioning in the Vicinity of Metamaterial Substrates by Simulating Emitter-Substrate Interactions

Sixteen New Cases Contributing to the Characterization of Patients with Distal 22q11.2 Microduplications.

Vertebrates that regenerate as models for guiding stem cels.

BI 5700, a Selective Chemical Inhibitor of IκB Kinase 2, Specifically Suppresses Epithelial-Mesenchymal Transition and Metastasis in Mouse Models of Tumor Progression.

Casein kinase 1 is required for efficient removal of Rec8 during meiosis I.

Photounbinding of calmodulin from a family of CaM binding peptides.

The role of Tuba1a in adult hippocampal neurogenesis and the formation of the dentate gyrus.

Proteomic analysis of the outer membrane of Protochlamydia amoebophila elementary bodies.

From an electrophoretic mobility shift assay to isolated transcription factors: a fast genomic-proteomic approach.

Laser microsurgery provides evidence for merotelic kinetochore attachments in fission yeast cells lacking Pcs1 or Clr4.

Leptotene/zygotene chromosome movement via the SUN/KASH protein bridge in Caenorhabditis elegans.

Proteomic analysis of endosomes from genetically modified p14/MP1 mouse embryonic fibroblasts.

Regulation of Tbx22 during facial and palatal development.

Sexual dimorphism in the fly brain.

Cellular organization of the neural circuit that drives Drosophila courtship behavior.

The actin cytoskeleton in whole mount preparations and sections.

Annexin A1 attenuates EMT and metastatic potential in breast cancer.

Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.

CD14 is a coreceptor of Toll-like receptors 7 and 9.

Role of the RNA/DNA kinase Grc3 in transcription termination by RNA polymerase I.

Sororin mediates sister chromatid cohesion by antagonizing Wapl.

Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway.

Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain.

Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4.

Mcl-1 is essential for germinal center formation and B cell memory.

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.

An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo.

Peptide labeling with isobaric tags yields higher identification rates using iTRAQ 4-plex compared to TMT 6-plex and iTRAQ 8-plex on LTQ Orbitrap.

Transcriptional repression of ceramide kinase in LPS-challenged macrophages.

Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded.

Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production.

Organization and coordinated assembly of the type III secretion export apparatus.

Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation.

Navigating intermediate targets: the nervous system midline.

MRE11 and COM1/SAE2 are required for double-strand break repair and efficient chromosome pairing during meiosis of the protist Tetrahymena.

An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila.

Raman microspectroscopy reveals long-term extracellular activity of Chlamydiae.

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.

Mechanistic concepts in X inactivation underlying dosage compensation in mammals.

Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation.

PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.

Sex peptide receptor and neuronal TOR/S6K signaling modulate nutrient balancing in Drosophila.

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes.

Peptide orientation affects selectivity in ion-exchange chromatography.

STAT5 in B cell development and leukemia.

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.

High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I.

Molecular transformers in the cell: lessons learned from the DegP protease-chaperone.

Tracing antigen signatures in the human IgE repertoire.

The Set3/Hos2 histone deacetylase complex attenuates cAMP/PKA signaling to regulate morphogenesis and virulence of Candida albicans.

CD271 antigen defines a subset of multipotent stromal cells with immunosuppressive and lymphohematopoietic engraftment-promoting properties.

QIKS--Quantitative identification of kinase substrates.

A model for cyst lumen expansion and size regulation via fluid secretion.

The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes.

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.

Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.

Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors.

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues.

NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells.

Electron tomography reveals unbranched networks of actin filaments in lamellipodia.

B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase.

The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex.

Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.

RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila.

Topology and organization of the Salmonella typhimurium type III secretion needle complex components.

Probing the phosphoproteome of HeLa cells using nanocast metal oxide microspheres for phosphopeptide enrichment.

Tuba8 is expressed at low levels in the developing mouse and human brain.

X inactivation and disease.

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.

Cortical domain correction repositions the polarity boundary to match the cytokinesis furrow in C. elegans embryos.

Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia.

Developmental gene regulation in the era of genomics.

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.

A new acid mix enhances phosphopeptide enrichment on titanium- and zirconium dioxide for mapping of phosphorylation sites on protein complexes.

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

MIPs are ancestral ligands for the sex peptide receptor.

Morphologic, functional, and occlusal characterization of mandibular lateral displacement malocclusion.

Expression and regulation of ANTXR1 in the chick embryo.

Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58).

A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission.

G9a and Glp methylate lysine 373 in the tumor suppressor p53.

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.

Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma.

Type III secretion systems shape up as they ship out.

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.

Conversion of a regulatory into a degradative protease.

Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.

Human rhinovirus 14 enters rhabdomyosarcoma cells expressing icam-1 by a clathrin-, caveolin-, and flotillin-independent pathway.

Reducing the haystack to find the needle: improved protein identification after fast elimination of non-interpretable peptide MS/MS spectra and noise reduction.

The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation.

A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.

The structure of the Salmonella typhimurium type III secretion system needle shows divergence from the flagellar system.

Systematic genetic analysis of muscle morphogenesis and function in Drosophila.

Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence.

ConteXt of change--X inactivation and disease.

Distinct protein domains and expression patterns confer divergent axon guidance functions for Drosophila Robo receptors.

Polycomb complexes act redundantly to repress genomic repeats and genes.

Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate.

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.

The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.

Proteomic analysis of endosomes from genetically modified p14/MP1 mouse embryonic fibroblasts.

Epithelial-Mesenchymal Transition in Pancreatic Carcinoma

Fast near-field imaging of spectrally broad sources using layered metallic structures

Temperature dependence of the near-field superlensing effect for single metal layers and stacked metal-dielectric films

Multifrequency parallelized near-field optical imaging with anistropic metal-dielectric stacks

Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria.

Reprogramming of Xist against the pluripotent state in fusion hybrids.

Ambystoma mexicanum, the axolotl: a versatile amphibian model for regeneration, development, and evolution studies.

Axolotl (Ambystoma mexicanum) in vitro fertilization.

Generation of transgenic axolotls (Ambystoma mexicanum).

Axolotl (Ambystoma mexicanum) embryonic transplantation methods.

Grafting axolotl (Ambystoma mexicanum) limb skin and cartilage from GFP+ donors to normal hosts.

Axolotl (Ambystoma mexicanum) limb and tail amputation.

Learning the transcriptional regulatory code.

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.

Cancer progenitors and epigenetic contexts: an Xisting connection.

Defining a superlens operating regime for imaging fluorescent molecules.

Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V.

The protein tyrosine kinase Tec regulates mast cell function.

Stoichiometry determination of the MP1-p14 complex using a novel and cost-efficient method to produce an equimolar mixture of standard peptides.

An improved strategy for tandem affinity purification-tagging of Schizosaccharomyces pombe genes.

Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis.

Comparative genomics of gene regulation-conservation and divergence of cis-regulatory information.

Multiscale analysis of dynamics and interactions of heterochromatin protein 1 by fluorescence fluctuation microscopy.

X chromosome inactivation sparked by non-coding RNAs.

High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all.

The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli.

BrainGazer--visual queries for neurobiology research.

Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis.

Central control of fever and female body temperature by RANKL/RANK.

Transcriptional networks controlling skeletal development.

Peptidic small molecule activators of the stress sensor DegS.

Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1.

Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge.

Dynamic localisation of Ran GTPase during the cell cycle.

TNFalpha shedding and epidermal inflammation are controlled by Jun proteins.

Automated monitoring to reduce electron microscope downtime.

Induction of autophagy by spermidine promotes longevity.

Induction of RNA-directed DNA methylation upon decondensation of constitutive heterochromatin.

The temporomandibular joint in a rheumatoid arthritis patient after orthodontic treatment.

The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells.

Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I.

Oct4 to count 2.

Preventing carryover of peptides and proteins in nano LC-MS separations.

Considering the evolution of regeneration in the central nervous system.

Structural basis of substrate specificity of plant 12-oxophytodienoate reductases.

Breast cancer stem cells: eradication by differentiation therapy?

A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeast.

ANNIE: integrated de novo protein sequence annotation.

Turning meiosis into mitosis.

Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1p.

HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity.

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

How cohesin and CTCF cooperate in regulating gene expression.

With Happyhour, everyone's under the table.

Cohesin acetylation: from antiestablishment to establishment.

Beyond photobleaching, laser illumination unbinds fluorescent proteins.

Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint.

McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR.

Selectivity profiling of DegP substrates and inhibitors.

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi.

An innovative method to study target protein-drug interactions by mass spectrometry.

Charting the molecular network of the drug target Bcr-Abl.

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.

SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells.

Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis.

Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes.

Optimizing the performance of tin dioxide microspheres for phosphopeptide enrichment.

RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.

Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity.

The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor.

H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome.

Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.

Sensory neurons in the Drosophila genital tract regulate female reproductive behavior.

FLYSNPdb: a high-density SNP database of Drosophila melanogaster.

ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression.

Weak but uniform enrichment of the histone variant macroH2A1 along the inactive X chromosome.

Improving Phosphopeptide/Protein Identification Using a New Data Mining Framework for MS/MS Spectra Preprocessing

Novel insights into the flexibility of cell and positional identity during urodele limb regeneration.

Redundant mechanisms for regulation of midline crossing in Drosophila.

The cohesin complex and its roles in chromosome biology.

Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage.

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction.

Mutations in AtPS1 (Arabidopsis thaliana parallel spindle 1) lead to the production of diploid pollen grains.

Positional cloning by fast-track SNP-mapping in Drosophila melanogaster.

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation.

Identification of the human homolog of the imprinted mouse Air non-coding RNA.

DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena.

Arabidopsis SMG7 protein is required for exit from meiosis.

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells.

Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation.

When flies and mice develop cancer. Meeting on development and cancer.

Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation.

Expression and regulation of HTRA1 during chick and early mouse development.

Enhanced detection and identification of multiply phosphorylated peptides using TiO2 enrichment in combination with MALDI TOF/TOF MS.

Transcript versus transcription?

Wired for sex: the neurobiology of Drosophila mating decisions.

PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse.

Complications of needle electromyography: hematoma risk and correlation with anticoagulation and antiplatelet therapy.

The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion.

Longitudinal alteration of the occlusal plane and development of different dentoskeletal frames during growth.

Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase.

Unravelling the structure of the lamellipodium.

Architecture and flexibility of the yeast Ndc80 kinetochore complex.

Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.

Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides.

SHOC1, an XPF endonuclease-related protein, is essential for the formation of class I meiotic crossovers.

The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice.

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.

Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation.

Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis.

The different functions of Stat5 and chromatin alteration through Stat5 proteins.

A guide to accurate measurement of diffusion using fluorescence correlation techniques with blinking quantum dot nanoparticle labels.

Moving AHEAD with an international human epigenome project.

Podoplanin is a novel fos target gene in skin carcinogenesis.

Efficient adult skeletal muscle regeneration in mice deficient in p38beta, p38gamma and p38delta MAP kinases.

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

Developmental plasticity of lymphocytes.

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.

Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation.

Twenty years of cell-cycle conferences in Roscoff.

Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis.

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1.

Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis.

Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia.

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.

The Suv39h-HP1 histone methylation pathway is dispensable for enrichment and protection of cohesin at centromeres in mammalian cells.

Synergy of Eed and Tsix in the repression of Xist gene and X-chromosome inactivation.

Structural basis for the regulated protease and chaperone function of DegP.

Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2.

c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene.

Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease.

Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development.

Differential transcriptional modulation of biological processes in adipocyte triglyceride lipase and hormone-sensitive lipase-deficient mice.

B young again.

Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system.

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins.

Comparative analysis of sequence features involved in the recognition of tandem splice sites.

JunD suppresses bone formation and contributes to low bone mass induced by estrogen depletion.

Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway.

Neuroscience: hidden female talent.

Checkpoint control: the journey continues.

Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.

Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanisms.

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals.

The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila.

Ca2+/Calmodulin-dependent kinase II signaling causes skeletal overgrowth and premature chondrocyte maturation.

Developmentally informed research on the effectiveness of clinical trials: a primer for assessing how developmental issues may influence treatment responses among adolescents with alcohol use problems.

Micromanaging regeneration.

The Drosophila pheromone cVA activates a sexually dimorphic neural circuit.

Heads or tails: can Wnt tell which one is up?

Targeting c-Jun and JunB proteins as potential anticancer cell therapy.

High-resolution, high-throughput SNP mapping in Drosophila melanogaster.

The transmembrane protein Golden goal regulates R8 photoreceptor axon-axon and axon-target interactions.

Polo and Aurora kinases: lessons derived from chemical biology.

Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons.

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control.

Cohesin mediates transcriptional insulation by CCCTC-binding factor.

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis.

Antagonistic control of cell fates by JNK and p38-MAPK signaling.

Strategies for identifying RNA splicing regulatory motifs and predicting alternative splicing events.

A receptor that mediates the post-mating switch in Drosophila reproductive behaviour.

14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation.

GraFix: sample preparation for single-particle electron cryomicroscopy.

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation.

Epithelial Plasticity of Hepatocytes During Liver Tumor Progression

Role of Growth factors in Bone development and differentiation.

Annexin A2/P11 interaction: new insights into annexin A2 tetramer structure by chemical crosslinking, high-resolution mass spectrometry, and computational modeling.

p38alpha: a suppressor of cell proliferation and tumorigenesis.

Neurobiology of behaviour.

The complete removal of cohesin from chromosome arms depends on separase.

Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing.

Function of the Drosophila CPEB protein Orb2 in long-term courtship memory.

A clonal analysis of neural progenitors during axolotl spinal cord regeneration reveals evidence for both spatially restricted and multipotent progenitors.

A novel plant gene essential for meiosis is related to the human CtIP and the yeast COM1/SAE2 gene.

A conserved function for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination.

Molecular basis for skeletal variation: insights from developmental genetic studies in mice.

A chemical proteomics approach to phosphatidylinositol 3-kinase signaling in macrophages.

X inactivation Xplained.

Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression.

Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis.

Tandem affinity purification of functional TAP-tagged proteins from human cells.

The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation.

Spatial organization of a ubiquitous eukaryotic kinetochore protein network in Drosophila chromosomes.

Skeletal development--Wnts are in control.

The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.

Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase.

Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress.

Xist function: bridging chromatin and stem cells.

Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.

Dscam diversity is essential for neuronal wiring and self-recognition.

The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer.

Life beyond cleavage: the case of Ago2 and hematopoiesis.

p53 is regulated by the lysine demethylase LSD1.

Dimer composition and promoter context contribute to functional cooperation between AP-1 and NFAT.

A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database.

c-Myc is required for transformation of FDC-P1 cells by EGFRvIII.

Simultaneous generation of fra-2 conditional and fra-2 knock-out mice.

Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling.

Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.

Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.

Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome.

Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells.

JunB is a gatekeeper for B-lymphoid leukemia.

NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1.

A physical assay for sister chromatid cohesion in vitro.

The 20S proteasome isolated from Alzheimer's disease brain shows post-translational modifications but unchanged proteolytic activity.

p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway.

Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections.

Plasticity of mammalian myotubes upon stimulation with a thrombin-activated serum factor.

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila.

Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function.

MASPECTRAS: a platform for management and analysis of proteomics LC-MS/MS data.

LAP2alpha-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit.

The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosis.

Molecular biology. How and when the genome sticks together.

DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2.

Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action.

pkaPS: prediction of protein kinase A phosphorylation sites with the simplified kinase-substrate binding model.

Beta-catenin/LEF-1 signalling in breast cancer--central players activated by a plethora of inputs.

In vitro differentiation of murine embryonic stem cells toward a renal lineage.

Pax5: the guardian of B cell identity and function.

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia.

ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin.

Differential regulation of Foxo3a target genes in erythropoiesis.

Drosophila olfactory memory: single genes to complex neural circuits.

Acto-myosin reorganization and PAR polarity in C. elegans.

Towards complete sets of farnesylated and geranylgeranylated proteins.

PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression.

Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction.

The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression.

The ring between ring fingers (RBR) protein family.

Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation.

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.

Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation.

Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.

The transmembrane protein Kon-tiki couples to Dgrip to mediate myotube targeting in Drosophila.

Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes.

HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development.

Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3.

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells.

Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes.

RNA degradation in fission yeast mitochondria is stimulated by a member of a new family of proteins that are conserved in lower eukaryotes.

Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription.

Posttranslational modifications and subcellular localization signals: indicators of sequence regions without inherent 3D structure?

Cell biology: the checkpoint brake relieved.

Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function.

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.

PSD-95 is required for activity-driven synapse stabilization.

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.

A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone.

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Xist and the order of silencing.

Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.

BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias.

Ran and Rac in mouse eggs: cortical polarity and spindle positioning.

Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor.

Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions.

Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus.

Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5.

Identification of new targets using expression profiling.

High-throughput knockout screen in fission yeast.

A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation.

Isotope-labeled cross-linkers and Fourier transform ion cyclotron resonance mass spectrometry for structural analysis of a protein/peptide complex.

HPLC techniques for proteomics analysis--a short overview of latest developments.

fruitless regulates aggression and dominance in Drosophila.

Application of different fragmentation techniques for the analysis of phosphopeptides using a hybrid linear ion trap-FTICR mass spectrometer.

Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo.

p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis.

Reversibility of the differentiated state: regeneration in amphibians.

Wapl controls the dynamic association of cohesin with chromatin.

Repression of p53 activity by Smyd2-mediated methylation.

Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin.

Regulation of commissural axon pathfinding by slit and its Robo receptors.

Role of canonical Wnt-signalling in joint formation.

Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge.

Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit.

Cleaning of raw peptide MS/MS spectra: improved protein identification following deconvolution of multiply charged peaks, isotope clusters, and removal of background noise.

Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27.

Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1.

Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization.

Histone modification patterns associated with the human X chromosome.

Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication.

Mitotic activation of the kinase Aurora-A requires its binding partner Bora.

ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.

Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation.

Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis.

Phosphoproteomics strategies for the functional analysis of signal transduction.

The anaphase promoting complex/cyclosome: a machine designed to destroy.

Postnatal development of the murine cerebellar cortex: formation and early dispersal of basket, stellate and Golgi neurons.

A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced.

c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity.

The epigenetic magic of histone lysine methylation.

The polycomb group protein EZH2 is required for mammalian circadian clock function.

Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8.

Shared neural circuitry for female and male sexual behaviours in Drosophila.

Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing.

Cohesin and DNA damage repair.

STAT1 acts as a tumor promoter for leukemia development.

T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17.

The calmodulin pathway and evolution of elongated beak morphology in Darwin's finches.

Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1.

Histone modification and the control of heterochromatic gene silencing in Drosophila.

DOUTfinder--identification of distant domain outliers using subsignificant sequence similarity.

Resolution of chiasmata in oocytes requires separase-mediated proteolysis.

Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors.

Checkpoint activation: don't get mad too much.

Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes.

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

Post-transcriptional regulation of microRNA expression.

Autocrine PDGFR signaling promotes mammary cancer metastasis.

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging.

The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division.

A Wnt canon orchestrating osteoblastogenesis.

Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.

A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytes.

Cleavage of the siRNA passenger strand during RISC assembly in human cells.

A central role for central tolerance.

Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR.

Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis.

Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney.

Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state.

Multiple roles of mesenchymal beta-catenin during murine limb patterning.

Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells.

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase.

Microscopy of the Drosophila facet eye: vademecum for standardized fixation, embedding, and sectioning.

The role of human HtrA1 in arthritic disease.

Application of a sensitive collection heuristic for very large protein families: evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian lipases.

Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.

Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells.

Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.

How APC/C orders destruction.

The role of histone modifications in epigenetic transitions during normal and perturbed development.

Regulation of cancer cell migration and bone metastasis by RANKL.

Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.

Wiring stability of the adult Drosophila olfactory circuit after lesion.

The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction.

Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes.

A germline GFP transgenic axolotl and its use to track cell fate: dual origin of the fin mesenchyme during development and the fate of blood cells during regeneration.

Netrins guide Drosophila commissural axons at short range.

The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila.

Structural analysis of the ZEN-4/CeMKLP1 motor domain and its interaction with microtubules.

Sexual behaviour: do a few dead neurons make the difference?

Methods to measure ubiquitin-dependent proteolysis mediated by the anaphase-promoting complex.

Biomolecular Mechanisms with Computational Biology

Epigenetics

Electron Microscopy of Extracted Cytoskeletons: Negative Staining, Cryoelectron Microscopy and Correlation with Light Microscopy.

Bone and Cartilage.

Protein prenylation: an (almost) comprehensive overview on discovery history, enzymology and significance in physiology and disease.

Epigenetic control of lymphopoiesis.

Epigenom

Phosphoproteomics as a tool to unravel plant regulatory mechanisms

An ECT2-centralspindlin complex regulates the localization and function of RhoA.

Separase is required at multiple pre-anaphase cell cycle stages in human cells.

Chemical cross-linking and high-performance Fourier transform ion cyclotron resonance mass spectrometry for protein interaction analysis: application to a calmodulin/target peptide complex.

Control of Shugoshin function during fission-yeast meiosis.

Refinement and prediction of protein prenylation motifs.

Molecular processes during fat cell development revealed by gene expression profiling and functional annotation.

Cell size control: new evidence for a general mechanism.

Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.

JNK1 is not essential for TNF-mediated joint disease.

Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila.

Proximodistal identity during vertebrate limb regeneration is regulated by Meis homeodomain proteins.

Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells.

Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

TIS7 regulation of the beta-catenin/Tcf-4 target gene osteopontin (OPN) is histone deacetylase-dependent.

TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen.

Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family.

HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells.

Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin.

Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina.

Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte.

Fos/AP-1 proteins in bone and the immune system.

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.

Large-scale purification of the vertebrate anaphase-promoting complex/cyclosome.

Identification of cell cycle-dependent phosphorylation sites on the anaphase-promoting complex/cyclosome by mass spectrometry.

SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly.

Molecular requirements for epithelial-mesenchymal transition during tumor progression.

Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis.

Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth.

A topological interaction between cohesin rings and a circular minichromosome.

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling.

EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells.

Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system.