Publications Anna Obenauf | Scientific Papers Obenauf Lab

Ciriello, G., Magnani, L., Aitken, SJ., Akkari, L., Behjati, S., Hanahan, D., Landau, DA., Lopez-Bigas, N., Lupiáñez, DG., Marine, JC., Martin-Villalba, A., Natoli, G., Obenauf, AC., Oricchio, E., Scaffidi, P., Sottoriva, A., Swarbrick, A., Tonon, G., Vanharanta, S., Zuber, J. (2024)

Cancer Evolution: A Multifaceted Affair.

Cancer Discov. 14(1):36-48

Elewaut, A., Estivill, G., Bayerl, F., Castillon, L., Novatchkova, M., Pottendorfer, E., Hoffmann-Haas, L., Schönlein, M., Nguyen, TV., Lauss, M., Andreatta, F., Vulin, M., Krecioch, I., Bayerl, J., Pedde, AM., Fabre, N., Holstein, F., Cronin, SM., Rieser, S., Laniti, DD., Barras, D., Coukos, G., Quek, C., Bai, X., Muñoz I Ordoño, M., Wiesner, T., Zuber, J., Jönsson, G., Böttcher, JP., Vanharanta, S., Obenauf, AC. (2024)

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity.

Nature.

Wilding, B., Woelflingseder, L., Baum, A., Chylinski, K., Vainorius, G., Gibson, N., Waizenegger, IC., Gerlach, D., Augsten, M., Spreitzer, F., Shirai, Y., Ikegami, M., Tilandyova, S., Scharn, D., Pearson, MA., Popow, J., Obenauf, AC., Yamamoto, N., Kondo, S., Opdam, FL., Bruining, A., Kohsaka, S., Kraut, N., Heymach, JV., Solca, F., Neumuller, RA. (2024)

Zongertinib (BI 1810631), an irreversible HER2 TKI, spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers.

Cancer Discov.

Bayerl, F., Meiser, P., Donakonda, S., Hirschberger, A., Lacher, SB., Pedde, AM., Hermann, CD., Elewaut, A., Knolle, M., Ramsauer, L., Rudolph, TJ., Grassmann, S., Öllinger, R., Kirchhammer, N., Trefny, M., Anton, M., Wohlleber, D., Höchst, B., Zaremba, A., Krüger, A., Rad, R., Obenauf, AC., Schadendorf, D., Zippelius, A., Buchholz, VR., Schraml, BU., Böttcher, JP. (2023)

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses.

Immunity. 56(6):1341-1358.e11

Leiendecker, L., Neumann, T., Jung, PS., Cronin, SM., Steinacker, TL., Schleiffer, A., Schutzbier, M., Mechtler, K., Kervarrec, T., Laurent, E., Bachiri, K., Coyaud, E., Murali, R., Busam, KJ., Itzinger-Monshi, B., Kirnbauer, R., Cerroni, L., Calonje, E., Rütten, A., Stubenrauch, F., Griewank, KG., Wiesner, T., Obenauf, AC. (2023)

Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell-like Program Conserved in HPV-Positive Cancers.

Cancer Discov. 13(1):70-84

Obenauf, AC. (2022)

Mechanism-based combination therapies for metastatic cancer.

Sci Transl Med. 14(655):eadd0887

Breitenecker, K., Homolya, M., Luca, AC., Lang, V., Trenk, C., Petroczi, G., Mohrherr, J., Horvath, J., Moritsch, S., Haas, L., Kurnaeva, M., Eferl, R., Stoiber, D., Moriggl, R., Bilban, M., Obenauf, AC., Ferran, C., Dome, B., Laszlo, V., Győrffy, B., Dezso, K., Moldvay, J., Casanova, E., Moll, HP. (2021)

Down-regulation of A20 promotes immune escape of lung adenocarcinomas.

Sci Transl Med. 13(601)

Haas L, Elewaut A, Gerard CL, Umkehrer C, Pedersen M, Leiendecker L, Krecioch I, Hoffmann D, Novatchkova M, Kuttke M, Neumann T, Pires de Silva I, Witthock H, Cuendet MA, Carotta S, Harrington KJ, Zuber J, Scolyer RA, Long GV, Wilmott JS, Michielin O, Vanharanta S, Wiesner T, Obenauf AC. (2021)

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma

Nature Cancer . 2:693–708

Haas, L., Elewaut, A., Gerard, CL., Umkehrer, C., Leiendecker, L., Pedersen, M., Krecioch, I., Hoffmann, D., Novatchkova, M., Kuttke, M., Neumann, T., da Silva, IP., Witthock, H., Cuendet, MA., Carotta, S., Harrington, KJ., Zuber, J., Scolyer, RA., Long, GV., Wilmott, JS., Michielin, O., Vanharanta, S., Wiesner, T., Obenauf, AC. (2021)

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma.

Nat Cancer. 2(7):693-708

Leiendecker, L., Jung, PS., Obenauf, AC. (2021)

Targeting CD56 with an antibody-drug conjugate in Merkel cell carcinoma.

Br J Dermatol.

Umkehrer, C., Holstein, F., Formenti, L., Jude, J., Froussios, K., Neumann, T., Cronin, SM., Haas, L., Lipp, JJ., Burkard, TR., Fellner, M., Wiesner, T., Zuber, J., Obenauf, AC. (2021)

Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters.

Nat Biotechnol. 39(2):174-178

Leiendecker, L., Jung, PS., Krecioch, I., Neumann, T., Schleiffer, A., Mechtler, K., Wiesner, T., Obenauf, AC. (2020)

LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma.

EMBO Mol Med. 12(11):e12525

Haas, L., Obenauf, AC. (2019)

Allies or Enemies-The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment.

Front Immunol. 10:2746

Benke, S., Agerer, B., Haas, L., Stöger, M., Lercher, A., Gabler, L., Kiss, I., Scinicariello, S., Berger, W., Bergthaler, A., Obenauf, AC., Versteeg, GA. (2018)

Human tripartite motif protein 52 is required for cell context-dependent proliferation.

Oncotarget. 9(17):13565-13581

Haas, L., Wiesner, T., Obenauf, AC. (2018)

A new era of proactive melanoma therapy: hit hard, hit early.

Br J Dermatol. 178(4):817-820

Muhar, M., Ebert, A., Neumann, T., Umkehrer, C., Jude, J., Wieshofer, C., Rescheneder, P., Lipp, JJ., Herzog, VA., Reichholf, B., Cisneros, DA., Hoffmann, T., Schlapansky, MF., Bhat, P., von Haeseler, A., Köcher, T., Obenauf, AC., Popow, J., Ameres, SL., Zuber, J. (2018)

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis.

Science. 360(6390):800-805

Massagué, J., Obenauf, AC. (2016)

Metastatic colonization by circulating tumour cells.

Nature. 529(7586):298-306

Mlecnik, B., Bindea, G., Angell, HK., Maby, P., Angelova, M., Tougeron, D., Church, SE., Lafontaine, L., Fischer, M., Fredriksen, T., Sasso, M., Bilocq, AM., Kirilovsky, A., Obenauf, AC., Hamieh, M., Berger, A., Bruneval, P., Tuech, JJ., Sabourin, JC., Le Pessot, F., Mauillon, J., Rafii, A., Laurent-Puig, P., Speicher, MR., Trajanoski, Z., Michel, P., Sesboüe, R., Frebourg, T., Pagès, F., Valge-Archer, V., Latouche, JB., Galon, J. (2016)

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.

Immunity. 44(3):698-711

Mlecnik, B., Bindea, G., Kirilovsky, A., Angell, HK., Obenauf, AC., Tosolini, M., Church, SE., Maby, P., Vasaturo, A., Angelova, M., Fredriksen, T., Mauger, S., Waldner, M., Berger, A., Speicher, MR., Pagès, F., Valge-Archer, V., Galon, J. (2016)

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.

Sci Transl Med. 8(327):327ra26

Jacob, LS., Vanharanta, S., Obenauf, AC., Pirun, M., Viale, A., Socci, ND., Massagué, J. (2015)

Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations.

Cancer Res. 75(18):3713-9

Obenauf, AC., Massagué, J. (2015)

Surviving at a distance: organ specific metastasis.

Trends Cancer. 1(1):76-91

Obenauf, AC., Zou, Y., Ji, AL., Vanharanta, S., Shu, W., Shi, H., Kong, X., Bosenberg, MC., Wiesner, T., Rosen, N., Lo, RS., Massagué, J. (2015)

Therapy-induced tumour secretomes promote resistance and tumour progression.

Nature. 520(7547):368-72

Wiesner, T., Lee, W., Obenauf, AC., Ran, L., Murali, R., Zhang, QF., Wong, EW., Hu, W., Scott, SN., Shah, RH., Landa, I., Button, J., Lailler, N., Sboner, A., Gao, D., Murphy, DA., Cao, Z., Shukla, S., Hollmann, TJ., Wang, L., Borsu, L., Merghoub, T., Schwartz, GK., Postow, MA., Ariyan, CE., Fagin, JA., Zheng, D., Ladanyi, M., Busam, KJ., Berger, MF., Chen, Y., Chi, P. (2015)

Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.

Nature. 526(7573):453-7

Mlecnik, B., Bindea, G., Angell, HK., Sasso, MS., Obenauf, AC., Fredriksen, T., Lafontaine, L., Bilocq, AM., Kirilovsky, A., Tosolini, M., Waldner, M., Berger, A., Fridman, WH., Rafii, A., Valge-Archer, V., Pagès, F., Speicher, MR., Galon, J. (2014)

Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients.

Sci Transl Med. 6(228):228ra37

Valiente, M., Obenauf, AC., Jin, X., Chen, Q., Zhang, XH., Lee, DJ., Chaft, JE., Kris, MG., Huse, JT., Brogi, E., Massagué, J. (2014)

Serpins promote cancer cell survival and vascular co-option in brain metastasis.

Cell. 156(5):1002-16

Bindea, G., Mlecnik, B., Tosolini, M., Kirilovsky, A., Waldner, M., Obenauf, AC., Angell, H., Fredriksen, T., Lafontaine, L., Berger, A., Bruneval, P., Fridman, WH., Becker, C., Pagès, F., Speicher, MR., Trajanoski, Z., Galon, J. (2013)

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

Immunity. 39(4):782-95

Katz, SF., Lechel, A., Obenauf, AC., Begus-Nahrmann, Y., Kraus, JM., Hoffmann, EM., Duda, J., Eshraghi, P., Hartmann, D., Liss, B., Schirmacher, P., Kestler, HA., Speicher, MR., Rudolph, KL. (2012)

Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation.

Gastroenterology. 142(5):1229-1239.e3

Mathiesen, RR., Fjelldal, R., Liestøl, K., Due, EU., Geigl, JB., Riethdorf, S., Borgen, E., Rye, IH., Schneider, IJ., Obenauf, AC., Mauermann, O., Nilsen, G., Christian Lingjaerde, O., Børresen-Dale, AL., Pantel, K., Speicher, MR., Naume, B., Baumbusch, LO. (2012)

High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer.

Int J Cancer. 131(4):E405-15

Wiesner, T., Obenauf, AC., Murali, R., Fried, I., Griewank, KG., Ulz, P., Windpassinger, C., Wackernagel, W., Loy, S., Wolf, I., Viale, A., Lash, AE., Pirun, M., Socci, ND., Rütten, A., Palmedo, G., Abramson, D., Offit, K., Ott, A., Becker, JC., Cerroni, L., Kutzner, H., Bastian, BC., Speicher, MR. (2011)

Germline mutations in BAP1 predispose to melanocytic tumors.

Nat Genet. 43(10):1018-21

Obenauf, AC., Schwarzbraun, T., Auer, M., Hoffmann, EM., Waldispuehl-Geigl, J., Ulz, P., Günther, B., Duba, HC., Speicher, MR., Geigl, JB. (2010)

Mapping of balanced chromosome translocation breakpoints to the basepair level from microdissected chromosomes.

J Cell Mol Med. 14(8):2078-84

Roetzer, KM., Schwarzbraun, T., Obenauf, AC., Hauser, E., Speicher, MR. (2010)

Further evidence for the pathogenicity of 15q24 microduplications distal to the minimal critical regions.

Am J Med Genet A. 152A(12):3173-8

Schallmoser, K., Bartmann, C., Rohde, E., Bork, S., Guelly, C., Obenauf, AC., Reinisch, A., Horn, P., Ho, AD., Strunk, D., Wagner, W. (2010)

Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions.

Haematologica. 95(6):867-74

Van Raamsdonk, CD., Griewank, KG., Crosby, MB., Garrido, MC., Vemula, S., Wiesner, T., Obenauf, AC., Wackernagel, W., Green, G., Bouvier, N., Sozen, MM., Baimukanova, G., Roy, R., Heguy, A., Dolgalev, I., Khanin, R., Busam, K., Speicher, MR., O'Brien, J., Bastian, BC. (2010)

Mutations in GNA11 in uveal melanoma.

N Engl J Med. 363(23):2191-9

Wiesner, T., Obenauf, AC., Cota, C., Fried, I., Speicher, MR., Cerroni, L. (2010)

Alterations of the cell-cycle inhibitors p27(KIP1) and p16(INK4a) are frequent in blastic plasmacytoid dendritic cell neoplasms.

J Invest Dermatol. 130(4):1152-7

Begus-Nahrmann, Y., Lechel, A., Obenauf, AC., Nalapareddy, K., Peit, E., Hoffmann, E., Schlaudraff, F., Liss, B., Schirmacher, P., Kestler, H., Danenberg, E., Barker, N., Clevers, H., Speicher, MR., Rudolph, KL. (2009)

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.

Nat Genet. 41(10):1138-43

Geigl, JB., Obenauf, AC., Waldispuehl-Geigl, J., Hoffmann, EM., Auer, M., Hörmann, M., Fischer, M., Trajanoski, Z., Schenk, MA., Baumbusch, LO., Speicher, MR. (2009)

Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays.

Nucleic Acids Res. 37(15):e105

Reinisch, A., Hofmann, NA., Obenauf, AC., Kashofer, K., Rohde, E., Schallmoser, K., Flicker, K., Lanzer, G., Linkesch, W., Speicher, MR., Strunk, D. (2009)

Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo.

Blood. 113(26):6716-25

Schallmoser, K., Rohde, E., Bartmann, C., Obenauf, AC., Reinisch, A., Strunk, D. (2009)

Platelet-derived growth factors for GMP-compliant propagation of mesenchymal stromal cells.

Biomed Mater Eng. 19(4-5):271-6

Schwarzbraun, T., Obenauf, AC., Langmann, A., Gruber-Sedlmayr, U., Wagner, K., Speicher, MR., Kroisel, PM. (2009)

Predictive diagnosis of the cancer prone Li-Fraumeni syndrome by accident: new challenges through whole genome array testing.

J Med Genet. 46(5):341-4

Wiesner, T., Obenauf, AC., Geigl, JB., Vallant, EM., Speicher, MR., Fink-Puches, R., Kerl, H., Cerroni, L. (2009)

9p21 deletion in primary cutaneous large B-cell lymphoma, leg type, may escape detection by standard FISH assays.

J Invest Dermatol. 129(1):238-40

Geigl, JB., Obenauf, AC., Schwarzbraun, T., Speicher, MR. (2008)

Defining 'chromosomal instability'.

Trends Genet. 24(2):64-9

Schallmoser, K., Rohde, E., Reinisch, A., Bartmann, C., Thaler, D., Drexler, C., Obenauf, AC., Lanzer, G., Linkesch, W., Strunk, D. (2008)

Rapid large-scale expansion of functional mesenchymal stem cells from unmanipulated bone marrow without animal serum.

Tissue Eng Part C Methods. 14(3):185-96

Publications

2024

2023

2022

2021

2020

2019

2018

2016

2015

2014

2013

2012

2011

2010

2009

2008

Cookie Settings