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Moritz Gaidt

The innate immune system detects pathogens and initiates host defences. Canonical detection of pathogens as “non-self” relies on sensing of microbial components, including lipopolysaccharide and nucleic acids, as pathogen-associated molecular patterns (PAMPs) by germline-encoded pattern recognition receptors (PRRs). PRRs activate the immune system to induce inflammation, to recruit and alert immune cells, and to defend against the intruder. Pathogens aim to avoid immune defences leading to a molecular arms race between pathogens and their hosts. We use functional genomics to identify genetic components of host-pathogen interactions, innate immune sensing, and immune homeostasis.

Publications

2023

Remick, BC., Gaidt, MM., Vance, RE. (2023)

Effector-Triggered Immunity.

 Annu Rev Immunol.

2022

Pinci, F., Gaidt, MM., Jung, C., Nagl, D., Kuut, G., Hornung, V. (2022)

Tumor necrosis factor is a necroptosis-associated alarmin.

 Front Immunol. 13:1074440
Schmacke, NA., O'Duill, F., Gaidt, MM., Szymanska, I., Kamper, JM., Schmid-Burgk, JL., Mädler, SC., Mackens-Kiani, T., Kozaki, T., Chauhan, D., Nagl, D., Stafford, CA., Harz, H., Fröhlich, AL., Pinci, F., Ginhoux, F., Beckmann, R., Mann, M., Leonhardt, H., Hornung, V. (2022)

IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network.

 Immunity. 55(12):2271-2284.e7

2021

Gaidt, MM., Morrow, A., Fairgrieve, MR., Karr, JP., Yosef, N., Vance, RE. (2021)

Self-guarding of MORC3 enables virulence factor-triggered immunity.

 Nature. 600(7887):138-142
Ji, DX., Witt, KC., Kotov, DI., Margolis, SR., Louie, A., Chevée, V., Chen, KJ., Gaidt, MM., Dhaliwal, HS., Lee, AY., Nishimura, SL., Zamboni, DS., Kramnik, I., Portnoy, DA., Darwin, KH., Vance, RE. (2021)

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons.

 Elife. 10

2020

Pinci, F., Gaidt, MM., Jung, C., Kuut, G., Jackson, MA., Bauernfried, S., Hornung, V. (2020)

C-tag TNF: a reporter system to study TNF shedding.

 J Biol Chem. 295(52):18065-18075

2019

Greulich, W., Wagner, M., Gaidt, MM., Stafford, C., Cheng, Y., Linder, A., Carell, T., Hornung, V. (2019)

TLR8 Is a Sensor of RNase T2 Degradation Products.

 Cell. 179(6):1264-1275.e13
Lehle, AS., Farin, HF., Marquardt, B., Michels, BE., Magg, T., Li, Y., Liu, Y., Ghalandary, M., Lammens, K., Hollizeck, S., Rohlfs, M., Hauck, F., Conca, R., Walz, C., Weiss, B., Lev, A., Simon, AJ., Groß, O., Gaidt, MM., Hornung, V., Clevers, H., Yazbeck, N., Hanna-Wakim, R., Shouval, DS., Warner, N., Somech, R., Muise, AM., Snapper, SB., Bufler, P., Koletzko, S., Klein, C., Kotlarz, D. (2019)

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.

 Gastroenterology. 156(1):275-278
Li, Y., Führer, M., Bahrami, E., Socha, P., Klaudel-Dreszler, M., Bouzidi, A., Liu, Y., Lehle, AS., Magg, T., Hollizeck, S., Rohlfs, M., Conca, R., Field, M., Warner, N., Mordechai, S., Shteyer, E., Turner, D., Boukari, R., Belbouab, R., Walz, C., Gaidt, MM., Hornung, V., Baumann, B., Pannicke, U., Al Idrissi, E., Ali Alghamdi, H., Sepulveda, FE., Gil, M., de Saint Basile, G., Hönig, M., Koletzko, S., Muise, AM., Snapper, SB., Schwarz, K., Klein, C., Kotlarz, D. (2019)

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases.

 Proc Natl Acad Sci U S A. 116(3):970-975
Pre-printSchmacke, NA.*, Gaidt, M.M.*, Szymanska, I., O’Duill, F., Stafford, CA., Chauhan, D., Fröhlich, AL., Nagl, D., Pinci, F., Schmid-Burgk, JL., Hornung, V. (2019)

Priming enables a NEK7-independent route of NLRP3 activation

 bioRxiv. 10.1101/799320

2018

Chauhan, D., Bartok, E., Gaidt, MM., Bock, FJ., Herrmann, J., Seeger, JM., Broz, P., Beckmann, R., Kashkar, H., Tait, SWG., Müller, R., Hornung, V. (2018)

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.

 Cell Rep. 25(9):2354-2368.e5
Gaidt, MM., Hornung, V. (2018)

The NLRP3 Inflammasome Renders Cell Death Pro-inflammatory.

 J Mol Biol. 430(2):133-141
Gaidt, MM., Rapino, F., Graf, T., Hornung, V. (2018)

Modeling Primary Human Monocytes with the Trans-Differentiation Cell Line BLaER1.

 Methods Mol Biol. 1714:57-66

2017

Andreeva, L., Hiller, B., Kostrewa, D., Lässig, C., de Oliveira Mann, CC., Jan Drexler, D., Maiser, A., Gaidt, M., Leonhardt, H., Hornung, V., Hopfner, KP. (2017)

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.

 Nature. 549(7672):394-398
Gaidt, MM., Ebert, TS., Chauhan, D., Ramshorn, K., Pinci, F., Zuber, S., O'Duill, F., Schmid-Burgk, JL., Hoss, F., Buhmann, R., Wittmann, G., Latz, E., Subklewe, M., Hornung, V. (2017)

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

 Cell. 171(5):1110-1124.e18
Gaidt, MM., Hornung, V. (2017)

Alternative inflammasome activation enables IL-1β release from living cells.

 Curr Opin Immunol. 44:7-13
Zinecker, H., Ouaret, D., Ebner, D., Gaidt, MM., Taylor, S., Aulicino, A., Jagielowicz, M., Hornung, V., Simmons, A. (2017)

ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect.

 Oncotarget. 8(63):106764-106777

2016

Gaidt, MM., Ebert, TS., Chauhan, D., Schmidt, T., Schmid-Burgk, JL., Rapino, F., Robertson, AA., Cooper, MA., Graf, T., Hornung, V. (2016)

Human Monocytes Engage an Alternative Inflammasome Pathway.

 Immunity. 44(4):833-46
Gaidt, MM., Hornung, V. (2016)

Pore formation by GSDMD is the effector mechanism of pyroptosis.

 EMBO J. 35(20):2167-2169
Schmidt, T., Schmid-Burgk, JL., Ebert, TS., Gaidt, MM., Hornung, V. (2016)

Designer Nuclease-Mediated Generation of Knockout THP1 Cells.

 Methods Mol Biol. 1338:261-72

2015

Schmid-Burgk, JL., Gaidt, MM., Schmidt, T., Ebert, TS., Bartok, E., Hornung, V. (2015)

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.

 Eur J Immunol. 45(10):2911-7

2014

Mankan, AK., Schmidt, T., Chauhan, D., Goldeck, M., Höning, K., Gaidt, M., Kubarenko, AV., Andreeva, L., Hopfner, KP., Hornung, V. (2014)

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.

 EMBO J. 33(24):2937-46
Schmid-Burgk, JL., Schmidt, T., Gaidt, MM., Pelka, K., Latz, E., Ebert, TS., Hornung, V. (2014)

OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines.

 Genome Res. 24(10):1719-23

2012

Abdullah, Z., Geiger, S., Nino-Castro, A., Böttcher, JP., Muraliv, E., Gaidt, M., Schildberg, FA., Riethausen, K., Flossdorf, J., Krebs, W., Chakraborty, T., Kurts, C., Schultze, JL., Knolle, PA., Klotz, L. (2012)

Lack of PPARγ in myeloid cells confers resistance to Listeria monocytogenes infection.

 PLoS One. 7(5):e37349

Publications will be listed soon. In the meantime, please refer to pubmed.