Tim Clausen
Our group employs an integrative Structural Biology approach to study complex proteases and chaperones that function as safeguards in the cell, preventing other proteins from undergoing dangerous interactions. By addressing mechanistic details of the protein-quality-control machinery, we aim to develop strategies against misbehaving proteins connected with neurodegenerative diseases, inclusion body myopathies, cancer and ageing. Moreover, differences in the protein folding and protein degradation pathways between bacterial pathogens and their hosts will guide the development of novel antibiotics.